EP.FRI.241 Negative appendicectomy rate and role of biomarkers in predicting the severity of acute appendicitis

Abstract Aim Acute appendicitis is the most common general surgical emergency. A recent consensus study has proposed a 10% negative appendicectomy rate. We aimed to determine rate in our centre whilst evaluating role of biomarkers predicting severity appendicitis. Methods single-centre retrospective analysis consecutive laparoscopic appendicectomies from 2019-2020 was performed. Patients were categorised by using AAST grading system. Kruskal-Wallis test used compare levels (WCC, CRP, bilirubin, neutrophil:lymphocyte ratio (NLR) and platelet:lymphocyte (PLR)). T-test, ROC curve Fisher’s exact differentiate between perforated non-perforated WCC ≥11, CRP ≥50, bilirubin ≥21, NLR ≥6.4 PLR ≥153 cut-off values. Negative defined as normal appendix at histopathological analysis. Results 224 patients included; mean age 33.7 years, 57.1% male. 17 (7.6%) had appendicectomy. NLR, increase with score (P < 0.001). ≥11 (p 0.001) = 0.007) predicted acute 0.018), 0.001), 0.002) predictive for appendiceal perforation. Conclusion 7.6% below recommended standard lower than other centres. In centre, raised WCC, may be distinguish Our results add conflicting body evidence relating